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Genome Dynamics Research Group

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ABOUT US

Genome Dynamics Research Group conducts interdisciplinary research in the field of biological sciences, biotechnology and molecular medicine. The group’s main areas of interest are DNA repair mechanisms, mutation fixation processes and evolution of the genome structure. The team is also working on understanding the basis of cancer development, with particular emphasis on the role of DNA repair processes, and the search for biomarkers and new candidates for innovative anti-cancer drugs.

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SENIOR LEADER
Michał Malewicz, Ph.D.

 

Team
 
RESEARCH
 
TECHNIQUES
 
Publications
 
  • Michał Malewicz, Ph.D. (Senior leader)
  • Paulina Wróbel (Lab Manager)

Open positions available in the lab.
Join us: e-mail: michal.malewicz@port.lukasiewicz.gov.pl

Our research focuses on understanding molecular mechanisms of DNA damage response (DDR) in mammalian cells. Defective DDR contributes to many human diseases including cancer. We use proteomics, gene knockout and genome engineering tools to identify new DDR proteins and their mode of action. We have a particular interest in studying mechanisms of repair for so-called double strand DNA breaks (DSBs). We have identified key new proteins acting in DSB repair pathways (e.g. PAXX). Our current studies will focus on finding novel links between DDR and human disease including rare disease and cancer.
  • CRISPR/Base editing
  • AAV
  • lentiviruses
  • iPS-based models
  • laser-induced micro-irradiation of life cells
  • organoids
Nicolai S, Mahen R, Raschellà G, Marini A, Pieraccioli M, Malewicz M, Venkitaraman AR, Melino G.
ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Oncogene, (2020); 39(4):754-766
 
Skalka G, Hall H, Somers J, Bushell M, Willis A, Malewicz M.
Leucine Zipper and ICAT Domain Containing (LZIC) Protein Regulates Cell Cycle Transitions in Response to Ionizing Radiation. Cell Cycle, (2019);18(9):963-975
 
Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I and MALEWICZ M.
NR4A nuclear receptors target poly-ADP-ribosylated DNA-PKcs protein to promote DNA repair. Cell Reports, (2019); 26 (8): 2028-2036
 
Craxton A, Munnur D, Jukes-Jones R, Skalka G, Langlais C, Cain K and MALEWICZ M.
PAXX and its paralogs synergistically direct DNA Polymerase lamba activity in DNA repair. Nature Communications, (2018); 9:3877
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Posted by Sieć Badawcza Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii, Posted on 07.01.2021
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